The Cannabinoid Receptors

The Cannabinoid Receptors PDF
Author: Patricia H. Reggio
Publisher: Springer Science & Business Media
ISBN: 9781597455039
Size: 17.90 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 402
View: 5695

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As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream. In The Cannabinoid Receptors, leading experts introduce newcomers to the cannabinoid field with chapters covering cannabinoid ligand synthesis and structure activity relationships, the molecular pharmacology of the cannabinoid receptors and the endocannabinoid system, and ultimately, the whole animal pharmacology and therapeutic applications for cannabinoid drugs. Adding to those key topics, the book also examines the current direction of the field with chapters on new putative cannabinoid receptors and challenges for future research. As a part of The Receptors TM series, this volume highlights its receptor with the most thorough, focused and essential information available. Comprehensive and cutting-edge, The Cannabinoid Receptors serves as an ideal guidebook to what continues to be a fascinating and vital field.

Recent Advances In Cannabinoid Physiology And Pathology

Recent Advances in Cannabinoid Physiology and Pathology PDF
Author: Anna N. Bukiya
Publisher: Springer
ISBN: 303021737X
Size: 36.42 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 167
View: 7704

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The cannabinoid system plays a central role in a wide variety of physiological functions that touch upon cardiovascular, gastrointestinal, immune, and nervous systems. Cannabinoids also play a central role in developmental physiology, management of pain, and shaping of human behaviour. Recent movements towards legalization of marijuana use have bolstered scientific interest in the cannabinoid field and led to research efforts that would unveil multi-faceted effects and mechanisms of cannabinoid presence in different organs and at various stages of development. This book summarizes the recent advances in the field of cannabinoid research at multiple levels of resolution. It spans from systemic effects of cannabinoids on development, physiological function, and prevalent pathophysiological conditions to mechanisms that govern cannabinoid interaction with their relevant protein targets at atomic resolution. This book will be of interest to a specialized audience in the fields of biochemistry, pharmacology and developmental biology but alsoto a wider readership with interest in general physiology and cannabinoid signalling in biological systems.

Cannabinoid Receptors

Cannabinoid Receptors PDF
Author: Roger G. Pertwee
Publisher:
ISBN:
Size: 65.37 MB
Format: PDF, Kindle
Category : Cannabinoids
Languages : en
Pages : 264
View: 1633

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Thus cannabinoid research must now extend well beyond the realms of pharmacology and molecular biology into those of physiology and pathophysiology.

The Cannabinoid Receptor Agonist Win55 212 Reduces Consequences Of Status Epilepticus In Rats

The Cannabinoid Receptor Agonist WIN55 212 Reduces Consequences of Status Epilepticus in Rats PDF
Author:
Publisher:
ISBN:
Size: 46.33 MB
Format: PDF, Kindle
Category :
Languages : en
Pages :
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Highlights: Effects of endocannabinoid agonist WIN5521-2 were studied in a post-status model. A dose of WIN given 4 h after status epilepticus (SE) suppressed early seizures. The WIN injection suppressed spike–wave activity in latent period (1–2 post-SE weeks). The WIN treatment did not prevent late seizure development but reduced mortality rate. The injection of WIN improved cell survival in the dentate hilar region after SE. Abstract: An acute brain insult can cause a spectrum of primary and secondary pathologies including increased risk for epilepsy, mortality and neurodegeneration. The endocannabinoid system, involved in protecting the brain against network hyperexcitability and excitotoxicity, is profoundly dysregulated by acute brain insults. We hypothesize that post-insult dysregulation of the endocannabinoid signaling may contribute to deleterious effects of an acute brain injury and potentiation of endocannabinoid transmission soon after an insult may reduce its pathological outcomes. Effects of an acute post-insult administration of the endocannabinoid receptor agonist WIN55, 212-2 on early seizure occurrence, animal mortality and hippocampal cell loss were studied in the lithium–pilocarpine status model. A single dose of WIN55, 212-2 (5 mg/kg) administered four hours after the end of status epilepticus (SE) reduced the incidence of early seizures during the first two post-SE days though did not change their duration and latency. Brief 4–6-Hz spike–wave discharges appeared de novo in the latent post-SE period and the acute administration of WIN55, 212-2 also reduced the incidence of the epileptiform events. A single dose of WIN55, 212-2 administered soon after SE improved survival of animals and reduced cell loss in the dentate hilus but did not prevent appearance of spontaneous recurrent seizures in the chronic period. Thus, a brief pharmacological stimulation of the endocannabinoid system soon after a brain insult exerts beneficial effects on its pathological outcome though does not prevent epileptogenesis.

Endocannabinoids

EndoCANNABINOIDS PDF
Author: Mary E. Abood
Publisher: Springer Science & Business Media
ISBN: 1461446686
Size: 79.32 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 288
View: 1088

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Featuring research from many of the leading scientists in the field, this volume complements recent publications describing cannabinoids, focusing on the physiological and therapeutic characteristics of compounds that modulate CB1 and CB2 receptor function.

Cannabinoids In Nature And Medicine

Cannabinoids in Nature and Medicine PDF
Author: Didier M. Lambert
Publisher: John Wiley & Sons
ISBN: 9783906390567
Size: 37.34 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 416
View: 4588

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The history and chemistry of one of mankind’s oldest drugs in one comprehensive volume! The first part of this volume focuses on the plant Cannabis sativa, its active ingredients, and the discovery of cannabinoid receptors, as well as the therapeutic applications of activating, or blocking, the receptors. Following an overview of the plant, its medicinal uses, and its preparations, further chapters cover biosynthetic pathways, pharmacological properties, cannabis-based medicine, toxicology, cannabis prohibition, and clinical situations where blocking the cannabinoid receptors might be beneficial. The second part covers the journey from humans to plants, analyzing anandamide, as well as other endocannabinoids and endocannabinoid congeners, biosynthetic pathways, current knowledge of FAAH-1, FAAH-2, monoglyceride lipase, and NAAA, concluding with new areas of research.

Cannabinoids

Cannabinoids PDF
Author: Vincenzo Di Marzo
Publisher: John Wiley & Sons
ISBN: 1118451279
Size: 78.83 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 320
View: 768

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‘Cannabinoids’ is a broad term covering a group ofnatural products from Cannabis sativa, one of which locks on tospecific receptors – protein molecules on the surface ofcells – known as cannabinoid receptors. Over the past decadesscientists have found that cannabinoid receptors and theirendogenous ligands, the endocannabinoids, are involved in a vastarray of physiological functions, including helping to controlbrain activity, energy metabolism, heart function, the immunesystem and even reproduction. In Cannabinoids, Vincenzo Di Marzo has assembled contributionsfrom international experts to provide the definitive guide to whatcontinues to be a rapidly developing research field. After anintroductory historical chapter, the book continues by looking atthe biochemical, genetic and molecular elements of cannabinoids,followed by chapters covering their role in health anddisease. The final chapter outlines the need for a newnomenclature to reflect the complex and multi-disciplinary natureof this area.

Cannabinoid Pharmacology

Cannabinoid Pharmacology PDF
Author:
Publisher: Academic Press
ISBN: 0128112336
Size: 18.70 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 492
View: 5946

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Cannabinoid Pharmacology, Volume 80 is a new volume in the Advances in Pharmacology that presents reviews of recent breakthroughs. This volume aims to present current knowledge of the endogenous cannabinoid system, and looks at molecular, cellular, tissue and organismal effects of endogenous and exogenous cannabinoids. Topics of note in this new volume include Endocannabinoids and their congeners, Endocannabinoid turnover, Plant cannabinoids, Synthetic cannabinoids and ‘legal highs’, CB1 and CB2 cannabinoid receptors, Novel signaling modalities, Novel cannabinoid receptors, and Ion channel regulation by cannabinoids. There is a broad coverage of the essential elements associated with the cannabinoid system. The Editors have sought to include authors who represent authoritative voices on these themes, but have not previously worked together to allow a fresh approach to the individual aspects covered. Presents reviews of recent breakthroughs in the cannabinoid system Features chapters from the best authors in the field Provides an essential resource for scientists, advanced undergraduate students through to established faculty members

Marijuana And The Cannabinoids

Marijuana and the Cannabinoids PDF
Author: Mahmoud A. ElSohly
Publisher: Springer Science & Business Media
ISBN: 1592599478
Size: 70.74 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 322
View: 3017

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Although primarily used today as one of the most prevalent illicit leisure drugs, the use of Cannabis sativa L., commonly referred to as marijuana, for medicinal purposes has been reported for more than 5000 years. Marijuana use has been shown to create numerous health problems, and, consequently, the expanding use beyond medical purposes into recreational use (abuse) resulted in control of the drug through international treaties. Much research has been carried out over the past few decades following the identification of the chemical structure of THC in 1964. The purpose of Marijuana and the Cannabinoids is to present in a single volume the comprehensive knowledge and experience of renowned researchers and scientists. Each chapter is written independently by an expert in his/her field of endeavor, ranging from the botany, the constituents, the chemistry and pharmacokinetics, the effects and consequences of illicit use on the human body, to the therapeutic potential of the cannabinoids.