Principles Of Proteomics

Principles of Proteomics PDF
Author: Richard Twyman
Publisher: Garland Science
ISBN: 0203507398
Size: 49.23 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 266
View: 733

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Principles of Proteomics is designed specifically to explain the different stages of proteomic analysis, their complexities and their jargon to students and researchers in a non-technical overview of the field. The author describes the broad range of problems which proteomics can address, including structural proteomics, interaction proteomics, protein modification analysis and functional proteomics. Methodologies are described in user-friendly language, from the more traditional two-dimensional gel electrophoresis to the new developments in protein chip technologies. These are well presented in the context of overall strategies which can be adopted to address the different aspects of large-scale protein analysis.

Principles Of Proteomics

Principles of Proteomics PDF
Author: Richard M. Twyman
Publisher: Garland Pub
ISBN: 9780815344728
Size: 66.81 MB
Format: PDF, Mobi
Category : Computers
Languages : en
Pages : 260
View: 687

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Principles of Proteomics, Second Edition, provides a concise and user-friendly introduction to the diverse technologies used for the large-scale analysis of proteins, as well as their applications, and their impact in areas such as drug discovery, agriculture, and the fight against disease. Proteomics is a fast-advancing field in which researchers seek to capture all the proteins in the cell and characterize them in ever more detail. Principles of Proteomics has been fully updated to reflect the most recent developments in the field without losing its focus on the underlying principles. With worked examples, case studies profiling both established and emerging technologies, and further reading lists for each chapter, Principles of Proteomics is an ideal introduction for students, researchers and those working in the industry.

Proteomics Principles Techniques And Analysis

Proteomics  Principles  Techniques and Analysis PDF
Author: Peter Wyatt
Publisher:
ISBN: 9781682865972
Size: 45.25 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 235
View: 3233

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The proteomes are a set of proteins that are produced by an organism. Proteomics helps in understanding the movement and interactions of proteins. Modern technologies have been introduced to develop a better understanding of proteomics. The common techniques used are mass spectrometry, differential in-gel electrophoresis, etc. This textbook, with its detailed analyses and data, will prove immensely beneficial to professionals and students involved in this area at various levels. The topics covered in this book offer the readers new insights in the field of proteomics.

Platelet Proteomics

Platelet Proteomics PDF
Author: Ángel García-Alonso
Publisher: John Wiley & Sons
ISBN: 0470463376
Size: 37.15 MB
Format: PDF, Docs
Category : Science
Languages : en
Pages : 424
View: 6405

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The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Proteomics In Foods

Proteomics in Foods PDF
Author: Fidel Toldrá
Publisher: Springer Science & Business Media
ISBN: 1461456266
Size: 46.28 MB
Format: PDF
Category : Technology & Engineering
Languages : en
Pages : 590
View: 7340

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Food proteomics is one of the most dynamic and fast-developing areas in food science. The goal of this book is to be a reference guide on the principles and the current and future potential applications of proteomics in food science and technology. More specifically, the book will discuss recent developments and the expected trends of the near future in food proteomics. The book will be divided into two parts. The first part (7 chapters) will focus on the basic principles for proteomics, e.g., sample preparation, such as extraction and separation techniques, analytical instrumentation currently in use, and available databases for peptide and protein identification. The second part of the book (26 chapters) will focus on applications in foods. It will deal with quality issues related to post-mortem processes in animal foods and quality traits for all foods in general, as well as the identification of bioactive peptides and proteins, which are very important from the nutritional point of view. Furthermore, consumers are now extremely susceptible to food safety issues, and proteomics can provide reassurance with different safety aspects, such as food authenticity, detection of animal species in the food, and identification of food allergens. All of these issues will be covered in this book. It is also worth noting that both editors are internationally recognized experts in the field of food science, and both have edited numerous food science books and handbooks.

Mass Spectrometry Data Analysis In Proteomics

Mass Spectrometry Data Analysis in Proteomics PDF
Author: Rune Matthiesen
Publisher: Springer Science & Business Media
ISBN: 1597452750
Size: 57.48 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 320
View: 6617

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The intention of Mass Spectrometry Data Analysis in Proteomics is to support researchers in deciding which programs to use in various tasks related to analysis of mass spectrometry data in proteomics. The chapters give a precise description of the theoretical background of each topic followed accurate descriptions of programs and the parameters best suited for different cases.

Proteomics And Metabolomics In Psychiatry

Proteomics and Metabolomics in Psychiatry PDF
Author: D. Martins-de-Souza
Publisher: Karger Medical and Scientific Publishers
ISBN: 331802600X
Size: 66.50 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 150
View: 4029

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This publication compiles data generated by proteomics and metabolomics about psychiatric disorders. Leading researchers in these fields review the basic principles of proteomics and metabolomics and propose the new directions to be followed in molecular psychiatry. The chapters divided into two sections – Schizophrenia/Psychotic Disorders and Mood Disorders – deal with findings in diverse tissues from human and preclinical models in order to unravel the biology and biochemistry behind the establishment and course of these illnesses as well as potential biomarkers for clinical applications. More than an update, this publication indicates the next steps to discover biomarkers and understand psychiatric disorders more comprehensively. This publication is valuable reading for psychiatrists, neuroscientists and analytical chemists interested in the basics of proteomics and metabolomics, psychiatric definitions and the most advanced hypotheses about the pathobiology of schizophrenia, depression and bipolar disorder.

Microarray Technology Through Applications

Microarray Technology Through Applications PDF
Author: Francesco Falciani
Publisher: Garland Science
ISBN: 1134182732
Size: 69.55 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 276
View: 1548

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Microarray Technology Through Applications provides the reader with an understanding, from an applications perspective, of the diverse range of concepts required to master the experimental and data analysis aspects of microarray technology. The first chapter is a concise introduction to the technology and provides the theoretical background required to understand the subsequent sections. The following chapters are a series of case studies representative of the most general and important applications of microarray technology, including CGH, analysis of gene expression, SNP arrays and protein arrays. The case studies are written by experts in the field and describe prototypic projects, indicating how to generalize the approach to similar studies. There are detailed step-by-step protocols describing the specific experimental and data analysis protocols mentioned in the case study section. There is also information on printing glass DNA microarray slides and data interpretation. Colour figures and data sets are provided on the website at http://www.garlandscience.com/9780415378536

Introduction To Proteomics

Introduction to Proteomics PDF
Author: Nawin C. Mishra
Publisher: John Wiley & Sons
ISBN: 047092084X
Size: 41.35 MB
Format: PDF, Kindle
Category : Science
Languages : en
Pages : 200
View: 1920

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Proteomics provides an introductory insight on proteomics, discussing the basic principles of the field, how to apply specific technologies and instrumentation, and example applications in human health and diseases. With helpful study questions, this textbook presents an easy to grasp and solid overview and understanding of the principles, guidelines, and especially the complex instrumentation operations in proteomics for new students and research scientists. Written by a leader in proteomics studies, Proteomics offers an expert perspective on the field and the future of proteomics.

Bioinformatics

Bioinformatics PDF
Author: Thomas Lengauer
Publisher: Vch Verlagsgesellschaft Mbh
ISBN: 9783527299881
Size: 56.86 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 700
View: 1472

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V.1: Basic technologies: From Genomes to drugs with bioinformatics (Thomas Lengauer); Sequence analysis (Martin Vingron); Structure, properties and computer identification of eukaryotic genes (Victor Solovyev). Analyzing regulatory regions in genomes (Thomas Werner). Homology modeling in biology and medicine (Roland L. Dunbrack, Jr.). Protein structure prediction (Ralf Zimmer and Thomas Lengauer). Protein-ligand docking in drug design (Matthias Rarey). Modellimg protein-protein and protein-DNA docking (Michael J. E. Sternberg and Gidon Moont). v.2: Applications: Integrating and accessing molecular biology resources (David P. Hansen and Thure Etzold). Bioinformatics support of genome sequencing projects (Xiaoqiu Huang). Analysis of sequence variations (Christopher S. Carlson, Mark J. Rieder and Deborah A. Nickerson). Proteome analysis (Pierre-Alain Binz, Elisabeth Gasteiger, Jean-Charles Sanchez, Amos Bairoch, Denis F. Hochstrasser, Ron D. Appel). Target finding in genomes and proteomes (Stephanie Fuhrman Liang, Xiling Wen and Roland Somogyi). Screening of drug databases (Martin Stahl, Matthias Rarey and Gerhard Klebe). Future trends (Thomas Lengauer).

Biomolecular Archaeology

Biomolecular Archaeology PDF
Author: T. A. Brown
Publisher: John Wiley & Sons
ISBN: 9781444392432
Size: 42.59 MB
Format: PDF, Kindle
Category : Social Science
Languages : en
Pages : 336
View: 1142

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Illustrated thoroughly, Biomolecular Archaeology is the first book to clearly guide students through the study of ancient DNA: how to analyze biomolecular evidence (DNA, proteins, lipids and carbohydrates) to address important archaeological questions. The first book to address the scope and methods of this new cross-disciplinary area of research for archaeologists Offers a completely up-to-date overview of the latest research in this innovative subject Guides students who wish to become biomolecular archaeologists through the complexities of both the scientific methods and archaeological goals. Provides an essential component to undergraduate and graduate archaeological research

Handbook Of Isoelectric Focusing And Proteomics

Handbook of Isoelectric Focusing and Proteomics PDF
Author: David Garfin
Publisher: Elsevier
ISBN: 0080533620
Size: 69.50 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 380
View: 3554

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Isoelectric focusing (IEF) is a high-resolution, stand-alone technique that can be used as an analytical method or tool for protein purification. The only current book on the market, the Handbook of Isoelectric Focusing and Proteomics is the ideal 'one-stop' source for germane information in this discipline. This highly practical book also contains chapters on alternative methods that may pave the way in the search for efficient techniques for fractionating and purifying proteins. Complete with the history of IEF focusing to authors' insights and practical tips, this book is a must for anyone working in proteomics. * Is the only current book available on the subject * Includes author insights and practical tips * Is an ideal single source for students and researchers working in proteomics

Principles Of Molecular Oncology

Principles of Molecular Oncology PDF
Author: Miguel H. Bronchud
Publisher: Springer Science & Business Media
ISBN: 1592596649
Size: 44.40 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 709
View: 2407

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At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.