Clinical Approach To Infection In The Compromised Host

Clinical Approach to Infection in the Compromised Host PDF
Author: R. Rubin
Publisher: Springer Science & Business Media
ISBN: 1461566452
Size: 76.10 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 685
View: 1146

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"Infection in the Compromised Host" has become a classic chapter in textbooks devoted to infectious diseases and internal medicine. The numbers of compromised hosts are increasing in the era of modem medicine because of our expanded capabilities to deal with difficult diseases, especially neoplasms. As a consequence, microbiologic complications related to the intensive care administered to these patients are increasing as well. Under these circum stances, not only does the underlying illness create conditions favorable for the development of unusual infections, but often the therapy contributes to the acquisition of potential pathogens that turn into agents responsible for severe and frequently fatal disease. Granulocytopenia and immunosuppression have been the two key fac tors in predisposing patients with cancer and other serious diseases to severe bacterial infections. Colonization by hospital-acquired pathogens and breaks in the anatomic barriers-as a result of disease or medical intervention-have contributed to the high incidence of infectious diseases in these patients. Although there is some overlap between the types of infection in granulocytopenic and immunosuppressed hosts, each ofthese clinical entities has distinctive features thatjustify considering them separately, reserving the term immunocompromised hosts only when refer ring to patients who are predisposed to opportunistic infections. For about two decades, infections in granulocytopenic patients have attracted the atten tion of clinicians because they represent a model for the study of antimicrobial drugs in hosts deprived of an essential element of defense against bacterial infection, that is, an adequate number of normally functioning granulocytes.

Clinical Approach To Infection In The Compromised Host

Clinical Approach to Infection in the Compromised Host PDF
Author: Robert H. Rubin
Publisher: Springer Science & Business Media
ISBN: 0306475278
Size: 53.75 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 734
View: 2878

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At the beginning of the new millennium, it is opportune to raveling of the molecular pathways of impaired host - review what has been accomplished in the field of infec- fense mechanisms and the characterization of the genetic tious diseases during the last decades of the previous mutations involved, with the prospect of novel strategies century. The paradigm of the immunocompromised host for therapeutic interventions and possible corrective gene has taught much about the pathophysiology of infectious therapy. In this foreword, I will take a helicopter view of diseases, particularly with regard to immunological as- the various aspects of host defense mechanisms with pects of host defense. In the beginning, Robert Good special emphasis on genetic factors, because of their re- called immunodeficiency syndromes “experiments of na- vance for the course and outcome of infections. ture. ” In the 1960s and subsequent decades, the clinical During life, there exist phases of age-related c- and immunological aspects of immune deficiencies were promised immune functions. After birth there is a phys- studied and adequate treatment attempted. A reflection of logical immune deficiency because the production of an- these developments were the three successful meetings on bodies commences slowly upon contact of the neonate these topics in Veldhoven, The Netherlands (1980), Stir- with microorganisms and upon vaccination.

Infectious Diseases In The Female Patient

Infectious Diseases in the Female Patient PDF
Author: Rudolph P. Galask
Publisher: Springer Science & Business Media
ISBN: 1461248523
Size: 79.20 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 264
View: 7212

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In obstetrics and gynecology, as in other medical disciplines, great satisfaction comes from doing, but a greater satisfaction comes from knowing. The desire to know raises clinical practice to its highest level. This principle guided us in determining the objectives for this volume. Several standard textbooks of obstetrics and gynecology include information about infectious problems. Infectious Diseases in the Female Patient is unique in that it emphasizes primarily the basic science as pects of infections in obstetrics and gynecology. Although providing a practitioner's handbook was not our goal, the reader nevertheless will find discussions of the management of infections in the female pa tient. The continued growth of knowledge about infectious disease en countered in obstetrics and gynecology has come from many sources: bacteriology, virology, genetics, immunology, biochemistry, physiol ogy, and pharmacology. Insights from all these disciplines contribute to the conceptual framework of this volume. Many of the authors who contributed to this text are leaders in their respective areas of research and bring to the book a diversity of ex pertise and experience. Controversial issues are developed in a bal anced fashion, and, in most cases, opposing views are discussed. Since medical texts usually are read piece-meal rather than cover to cover, we have allowed some overlap between chapters. The slight degree of redundancy allows each chapter to stand on its own, so that the reader may obtain the necessary information from a single chapter.

Head And Neck Management Of The Cancer Patient

Head and Neck Management of the Cancer Patient PDF
Author: Douglas E. Peterson
Publisher: Springer Science & Business Media
ISBN: 1461322898
Size: 45.30 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 529
View: 6122

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This book presents in a comprehensive way cur the clinical care of the patient with head and neck rent advances in the management of neoplasia cancer involvement and/or its complications. and associated complications of the head and Today's complex treatments in oncology re neck. A broad range of clinical considerations is quire a comprehensive approach to effect a posi discussed following overviews of relevant basic tive result for the cancer patient whose facial biologic issues and the roles of various disci appearance and function are compromised. We plines. Each chapter has been structured to trust that physicians, dentists, nurses, dental "stand by itself"; at the same time, obvious rela hygienists, and individuals in the supportive ser tionships with other chapters have been noted. vices involved in the management of the cancer We are pleased that this book represents, in our patient will find this book beneficial. opinion, a truly multidisciplinary approach to Xl I. INTRODUCTION 1. CANCER, ITS COMPLICATIONS, AND THE HEAD AND NECK Stephen T. Sanis Few diseases are as complex in their biology, tumors, such as colorectal cancers, seems physiology, pathology, or management as can equivocal [3]. cer [1, 2]. In addition, the disease concurrently has extensive psychological impact on patients.

Current Controversies In Bone Marrow Transplantation

Current Controversies in Bone Marrow Transplantation PDF
Author: Brian J. Bolwell
Publisher: Springer Science & Business Media
ISBN: 1592596576
Size: 26.74 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 322
View: 2389

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Leading transplant physicians critically review and interpret twenty-one key clinical challenges in bone marrow/hematopoietic cell transplantation, and offer their best personal recommendations for treatment. Topics range from transplant strategies to complications of bone marrow transplantation, including a discussion of the indications, benefits, and the risks for a variety of leukemias, lymphomas, and solid tumors. The authors debate such contentious issues as the appropriateness of transplants in older patients, how many stem cells are sufficient for engraftment, and the pros and cons of umbilical cord blood transplantation. Up-to-date and clinically focused, Current Controversies in Bone Marrow Transplantation offers clinical oncologists, hematology/oncology fellows in training, and residents in internal medicine today's best ready reference and management guide for all their critical oncologic problems arising from the use of bone marrow/stem cell transplantation.

Antimicrobial Prophylaxis In Urology With Special Reference To The New Quinolones

Antimicrobial Prophylaxis in Urology with special reference to the new Quinolones PDF
Author: T. Gasser
Publisher: Springer Science & Business Media
ISBN: 3642854222
Size: 41.67 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 76
View: 3926

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This monograph gives an excellent review of the issue of antimicrobial prophylaxis in urol ogy and the use of the new fluoroquinolones in urology. The development of the fluoro quinolones has had a profound effect in urology, specifically because of the unique phar macokinetics of the fluoroquinolones with their two or more pK values, making concen tration of these compounds possible in the prostate. Their wide spectra against infecting organisms causing infections in the urinary tract have also made them popular and almost ideal in the treatment of urinary tract infections. This thesis summarizes in an concise way and brings up to date practically all our know ledge concerning the use of fluoroquinolones in urology. The chapter on antimicrobial prophylaxis covers our present knowledge completely, especially concerning the use of these drugs in antimicrobial prophylaxis in transurethral surgery. September 1992 PaulO. Madsen Madison, Wisconsin, USA v Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . V I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 1. Author's Publications Referred to in Text . . . . . . . . . . . . . . . . . . . . . . 1 1. 2. Historical Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 3. Problems of Antimicrobial Prophylaxis in Urology . . . . . . . . . . . . . . . . 2 D. General Considerations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Definitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 1. Bacteriuria and urinary tract infections . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 2. Bacteremia and septicemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. 3. Nosocomial infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. 1. 4. Wound infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 2. Pathophysiology of Infection . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. 3. Specifics of Antimicrobial Agents to be Used in Prophylaxis . . . . . . . . . . 6 2. 4. Role of Quinolones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 4. 1. Antimicrobial activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2. 4. 2. Pharmacokinetic properties . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Uncommon Problems In Intensive Care

Uncommon Problems in Intensive Care PDF
Author: J. F. Cade
Publisher: Cambridge University Press
ISBN: 9781841100913
Size: 12.74 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 404
View: 4095

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Even the most experienced clinician cannot be expected to remember all the relevant details of so many and varied uncommon problems of the seriously ill. Some of these problems can be overlooked in even a major Intensive Care textbook, most can be found eventually in specialist textbooks but the impact on intensive care management might well still be disregarded. This book offers a unique approach. Uncommon problems relevant to intensive care have been gathered into a single volume, in which they have been described in sufficient detail to avert much of the need to refer to specialized texts. Moreover, their implications for intensive care management have been highlighted. The book is intended to provide an easy and practical reference, alphabetically arranged, for the clinician at any level faced with such problems at the patient's bedside.

Imaging Of Diseases Of The Chest E Book

Imaging of Diseases of the Chest E Book PDF
Author: David M. Hansell
Publisher: Elsevier Health Sciences
ISBN: 0723436673
Size: 61.63 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 1208
View: 716

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This is the ideal resource for all those requiring an authoritative and up-to-date review of imaging appearances of diseases of the lung, pleura and mediastinum. Chest radiography and CT are integrated with other imaging techniques, including MRI and PET, where appropriate. The clinical and pathologic features of different diseases are provided in varying degrees of detail with more in depth coverage given to rarer and less well understood conditions. A single volume, comprehensive reference text on chest radiology.Provides in a single resource all of the information a generalist in diagnostic radiology needs to know. Concisely and clearly written by a team of 4 internationally recognized authors.Avoids the inconsistency, repetition, and unevenness of coverage that is inherent in multi-contributed books. Multimodality coverage integrated throughout every chapter.All of the applicable imaging modalities are covered in a clinically relevant, diagnostically helpful way. Approximately 3,000 high quality, good-sized images.Provides a complete visual guide that the practitioner can refer to for help in interpretation and diagnosis. Covers both common and uncommon disorders.Provides the user with a single comprehensive resource, no need to consult alternative resources. Access the full text online and download images via Expert Consult Access the latest version of the Fleischner Society's glossary of terms for thoracic imaging. Outlines, summary boxes, key points used throughout.Makes content more accessible by highlighting essential information. Brand new color images to illustrate Functional imaging techniques.Many of the new imaging techniques can provide functional as well as anatomic information. Introduction of a second color throughout in summary boxes in order to better highlight key information. There’s a wealth of key information in the summary boxes—will be highlighted more from the narrative text and will therefore be easier to access. Practical tips on identifying anatomic variants and artefacts in order to avoid diagnostic pitfalls.Many misdiagnoses are the result of basic errors in correlating the anatomic changes seen with imaging to their underlying pathologic processes. Latest techniques in CT, MRI and PET as they relate to thoracic diseases. The pace of development in imaging modalities and new applications/refined techniques in existing modalities continues to drive radiology forward as a specialty. Emphasis on cost-effective image/modality selection.Addresses the hugely important issue of cost-containment by emphasizing which imaging modality is helpful and which is not in any given clinical diagnosis. COPD and Diffuse Lung Disease, Small Airway disease chapters extensively up-dated. Access the full text online and download images via Expert Consult Access the latest version of the Fleischner Society's glossary of terms for thoracic imaging.

Antibiotic And Chemotherapy E Book

Antibiotic and Chemotherapy E Book PDF
Author: Roger G. Finch
Publisher: Elsevier Health Sciences
ISBN: 0702047651
Size: 37.93 MB
Format: PDF
Category : Medical
Languages : en
Pages : 916
View: 7764

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Well-respected and widely regarded as the most comprehensive text in the field, Antibiotic and Chemotherapy, 9th Edition by Drs. Finch, Greenwood, Whitley, and Norrby, provides globally relevant coverage of all types of antimicrobial agents used in human medicine, including all antiviral, antiprotozoan and anthelminthic agents. Comprehensively updated to include new FDA and EMEA regulations, this edition keeps you current with brand-new information about antiretroviral agents and HIV, superficial and mucocutaneous myscoses and systemic infections, management of the immunocompromised patient, treatment of antimicrobial resistance, plus coverage of new anti-sepsis agents and host/microbe modulators. Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Offer the best possible care and information to your patients about the increasing problem of multi-drug resistance and the wide range of new antiviral therapies now available for the treatment of HIV and other viral infections. Stay current with 21 new chapters including the latest information on superficial and mucocutaneous mycoses, systemic infections, anti-retroviral agents, and HIV. Get fresh perspectives and insights thanks to 21 newly-authored and extensively re-written chapters. Easily access information thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Apply the latest treatments for anti-microbial organisms such as MRSA, and multi-drug resistant forms of TB, malaria and gonorrhea. Keep up on the latest FDA and EMEA regulations.

Infectious Complications In Transplant Recipients

Infectious Complications in Transplant Recipients PDF
Author: Nina Singh
Publisher: Springer Science & Business Media
ISBN: 1461514037
Size: 19.65 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 312
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Infectious Complications in Transplant Patients has been uniquely designed and formatted to address issues and trends pertaining to pathogens deemed important in critically ill transplant patients. The chapters have been carefully selected so as to direct the focus of the book towards current approaches to controversial, emerging or topical problems in these patients. Each chapter has been authored by a North American and a European specialist. This format serves to impart an added dimension reflective of the diversity of opinions and practices pertaining to unresolved or controversial issues. The authors are recognized experts in their respective fields.

Infectious Diseases

Infectious Diseases PDF
Author: Sherwood L. Gorbach
Publisher: Lippincott Williams & Wilkins
ISBN: 0781733715
Size: 13.85 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 2515
View: 7418

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The Third Edition of this definitive reference provides comprehensive guidelines on the diagnosis, treatment, and prevention of every infectious disease seen in current clinical practice. More than 300 world-class practitioners detail the full range of clinical infections, microorganisms, diagnostic tests, and antimicrobial therapies. Coverage includes chapters on surgical infections written by preeminent surgeons and up-to-the-minute information on HIV infection. A comprehensive antimicrobial drugs section includes tables that provide at-a-glance prescribing information. New Third Edition chapters cover bioterrorism, hospital infections, emerging infections, human herpesvirus-8, West Nile virus, food safety, linezolid and quinupristin/dalfopristin, molecular diagnostics, and diagnostic significance of nonspecific laboratory abnormalities.

Transplant Infections

Transplant Infections PDF
Author: Raleigh A. Bowden
Publisher: Lippincott Williams & Wilkins
ISBN: 1451148097
Size: 23.62 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 800
View: 1067

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Transplant Infections is a practical, clinically focused reference covering the common and more unusual bacterial, viral, and fungal infections affecting patients who have received stem cell or solid organ transplants. It provides a comprehensive review of the epidemiology, diagnosis, and management of opportunistic infections and presents strategies for infection prevention and control. Highlights of the Third Edition include a chapter on new immunosuppressive agents and expanded coverage of tropical infections and West Nile virus.

Diagnostic Pathology Of Infectious Disease E Book

Diagnostic Pathology of Infectious Disease E Book PDF
Author: Richard L. Kradin
Publisher: Elsevier Health Sciences
ISBN: 1455705985
Size: 43.32 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 660
View: 6035

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Diagnostic Pathology of Infectious Disease presents a comprehensive, organ-based approach to the effective and accurate diagnosis of infectious diseases. Dr. Richard L. Kradin covers the latest information on H1N1, as well as the use of immunohistochemical stains, PCR, Immunoperoxidase, and other molecular techniques for a current representation of the field. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion so you can quickly identify and diagnose whatever you see. This reference is an invaluable tool for the accurate diagnosis of any infectious disease—from the common to the most challenging. Covers the latest techniques in immunohistochemistry and molecular genetics integrated throughout the text for comprehensive information on all investigative contexts relevant to ensuring diagnostic accuracy. Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. Provides a complete visual guide to suspect lesions through superb, high-quality, full-color illustrations of key aspects of various diseases that facilitate the rapid identification of biopsy specimen. Presents contents organized by organ as opposed to pathogen to more effectively address diagnostic and management issues. Features tables that list differential diagnosis for each lesion for quick summaries of key points in problem areas. Highlights morphological characteristics and landmarks of tissue samples throughout the text for easy access to information necessary for signing out specimen. Focuses on clinicopathologic features and correlations so you can deal with the diagnostic problems you face every day.