Biomaterials Based Strategies For Skeletal Muscle Tissue Engineering Existing Technologies And Future Trends

Biomaterials Based Strategies for Skeletal Muscle Tissue Engineering  Existing Technologies and Future Trends PDF
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Size: 43.25 MB
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Languages : en
Pages :
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Abstract: Skeletal muscles have a robust capacity to regenerate, but under compromised conditions, such as severe trauma, the loss of muscle functionality is inevitable. Research carried out in the field of skeletal muscle tissue engineering has elucidated multiple intrinsic mechanisms of skeletal muscle repair, and has thus sought to identify various types of cells and bioactive factors which play an important role during regeneration. In order to maximize the potential therapeutic effects of cells and growth factors, several biomaterial based strategies have been developed and successfully implemented in animal muscle injury models. A suitable biomaterial can be utilized as a template to guide tissue reorganization, as a matrix that provides optimum micro-environmental conditions to cells, as a delivery vehicle to carry bioactive factors which can be released in a controlled manner, and as local niches to orchestrate in situ tissue regeneration. A myriad of biomaterials, varying in geometrical structure, physical form, chemical properties, and biofunctionality have been investigated for skeletal muscle tissue engineering applications. In the current review, we present a detailed summary of studies where the use of biomaterials favorably influenced muscle repair. Biomaterials in the form of porous three-dimensional scaffolds, hydrogels, fibrous meshes, and patterned substrates with defined topographies, have each displayed unique benefits, and are discussed herein. Additionally, several biomaterial based approaches aimed specifically at stimulating vascularization, innervation, and inducing contractility in regenerating muscle tissues are also discussed. Finally, we outline promising future trends in the field of muscle regeneration involving a deeper understanding of the endogenous healing cascades and utilization of this knowledge for the development of multifunctional, hybrid, biomaterials which support and enable muscle regeneration under compromised conditions.

Graphene Based Materials In Health And Environment

Graphene based Materials in Health and Environment PDF
Author: Gil Gonçalves
Publisher: Springer
ISBN: 3319456393
Size: 25.67 MB
Format: PDF, Docs
Category : Technology & Engineering
Languages : en
Pages : 356
View: 3068

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This book provides a comprehensive overview of the potential use of graphene-based materials in two important societal areas: medicine and the environment. It discusses how new graphene-based materials can be creatively used for biological purposes, for example as delivery vehicles for diagnostics or therapeutics, ultrasensitive sensors, smart responsive substrates for artificial-tissue design and biomarkers. Moreover, it presents new insights into their use as sorbent or photocatalytic materials for environmental decontamination in water and gas-phase desalination membranes and as sensors for contaminant monitoring, giving relevance to the current discussions on the possible toxicological effects of graphene-based materials.

Novel Biomaterials For Regenerative Medicine

Novel Biomaterials for Regenerative Medicine PDF
Author: Heung Jae Chun
Publisher: Springer
ISBN: 9811309477
Size: 64.68 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 537
View: 5155

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This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine.

Handbook Of Tissue Engineering Scaffolds Volume One

Handbook of Tissue Engineering Scaffolds  Volume One PDF
Author: Masoud Mozafari
Publisher: Woodhead Publishing
ISBN: 0081025645
Size: 10.74 MB
Format: PDF, Docs
Category : Technology & Engineering
Languages : en
Pages : 790
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Handbook of Tissue Engineering Scaffolds: Volume One, provides a comprehensive and authoritative review on recent advancements in the application and use of composite scaffolds in tissue engineering. Chapters focus on specific tissue/organ (mostly on the structure and anatomy), the materials used for treatment, natural composite scaffolds, synthetic composite scaffolds, fabrication techniques, innovative materials and approaches for scaffolds preparation, host response to the scaffolds, challenges and future perspectives, and more. Bringing all the information together in one major reference, the authors systematically review and summarize recent research findings, thus providing an in-depth understanding of scaffold use in different body systems. Dedicated to the specialist topic of composite scaffolds, featuring all human body systems Covers basic fundamentals and advanced clinical applications Includes up-to-date information on preparation methodology and characterization techniques Highlights clinical data and case studies

Physico Chemical Control Of Cell Function

Physico Chemical Control of Cell Function PDF
Author: Cesare Gargioli
Publisher: Frontiers Media SA
ISBN: 2889459985
Size: 11.72 MB
Format: PDF, ePub, Mobi
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Languages : en
Pages :
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Extracellular Matrix (ECM) has been considered for a long time merely a scaffold sustaining cell and tissue function. Despite this simplistic view shared by many, nowadays ECM and their mechanic-physical and chemical characteristic acquired a progressive larger role actively regulating cell life: survival, proliferation, gene expression and differentiation. The interplay between cells and the ECM is continuously controlled at the cell level in a dynamic way. While cells synthesize the raw components of the ECM, this in turn impacts on cell function by providing chemical, topographical and mechanical hints. Such stimuli have been proven to control several aspects of cell function, including survival, proliferation, differentiation and migration. The molecular pathways activated by cells in response to the physical cues arising from the ECM are being disclosed and thus the possibility to control cell function through materials design is becoming more realistic. Current in vitro protocols, relying in 2D cell culture system, entail reductionist approaches to the complexity of cell-ECM interaction and result in cells rapidly losing their distinctive functions in culture. Understanding and replicating the 3D microenvironmental cues affecting cell function appears as a mandatory requirement for the development of next-generation biomaterials, as well as for the establishment of more physiologically relevant and predictive in vitro models of diseases. Such an effort will require a multidisciplinary approach at the convergence of biophysics, biology, nanotechnology, and bioengineering.

Clinical Regenerative Medicine In Urology

Clinical Regenerative Medicine in Urology PDF
Author: Bup Wan Kim
Publisher: Springer
ISBN: 9811027234
Size: 24.83 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 285
View: 172

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This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. In providing clinicians and researchers with a broad perspective on the development of regenerative medicine technologies, it will assist in the dissemination of both regenerative medicine principles and a variety of exciting therapeutic options. After an opening section addressing current developments and future perspectives in tissue engineering and regenerative medicine, fundamentals such as cell technologies, biomaterials, bioreactors, bioprinting, and decellularization are covered in detail. The remainder of the book is devoted to the description and evaluation of a range of cell and tissue applications, with individual chapters focusing on the kidney, bladder, urethra, urethral sphincter, and penis and testis.

                                PDF
Author: ستيفن ولفرام
Publisher: ktab INC.
ISBN: 9772812436
Size: 20.12 MB
Format: PDF, ePub, Mobi
Category :
Languages : ar
Pages : 126
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منذ ثلاثة قرون حدث تحول درامي في العالم عندما ظهرت فكرة تستند على أن القواعد المبنية على المعادلات الرياضية يمكن أن تستخدم لوصف العالم الطبيعي من حولنا . هدف هذا الكتاب هو بدء تحول آخر ، و وضع مقدمة لعلم جديد مبنى على فكرة القواعد الأكثر شمولاً و عمومية الكامنة في (البرامج الحاسوبية البسيطة) .

Cancer New Insights For The Healthcare Professional 2011 Edition

Cancer  New Insights for the Healthcare Professional  2011 Edition PDF
Author:
Publisher: ScholarlyEditions
ISBN: 1464900027
Size: 70.50 MB
Format: PDF, Docs
Category : Medical
Languages : en
Pages : 3937
View: 4111

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Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.